|
KMID : 0923620140140020100
|
|
Immune Network
2014 Volume.14 No. 2 p.100 ~ p.106
|
|
|
Shigella flexneri Inhibits Intestinal Inflammation by Modulation of Host Sphingosine-1-Phosphate in Mice
|
|
Kim Young-In
Yang Jin-Young
Ko Hyun-Jeong
Kweon Mi-Na
Chang Sun-Young
|
|
|
Abstract
|
|
|
|
Infection with invasive Shigella species results in intestinal inflammation in humans but no symptoms in adult mice. To in-vestigate why adult mice are resistant to invasive shigellae, 6∼8-week-old mice were infected orally with S. flexneri 5a. Shigellae successfully colonized the small and large in-testines. Mild cell death was seen but no inflammation. The infected bacteria were cleared 24 hours later. Microarray analysis of infected intestinal tissue showed that several genes that are involved with the sphingosine-1-phosphate (S1P) signaling pathway, a lipid mediator which mediates im-mune responses, were altered significantly. Shigella in-fection of a human intestinal cell line modulated host S1P-re-lated genes to reduce S1P levels. In addition, co-admin-istration of S1P with shigellae could induce inflammatory re-sponses in the gut. Here we propose that Shigella species have evasion mechanisms that dampen host inflammatory responses by lowering host S1P levels in the gut of adult mice.
|
|
|
KEYWORD
|
|
|
Shigella flexneri, Inflammation, Sphingosine-1-phosphate, Intestine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|